Blue Jays vs. Astros Prediction, Odds, Picks - April 22

Data Skrive

The Toronto Blue Jays and George Springer will square off against the Houston Astros and Cam Smith on Tuesday at 8:10 p.m. ET, in the second game of a three-game series at Daikin Park. The Blue Jays have been listed as -111 moneyline favorites in this matchup with the Astros (-108). Toronto is the run-line favorite (-1.5). The over/under is 8 runs for this matchup (with -116 odds to hit the over and -105 odds to go under).

Check out everything you need to know from a betting perspective on the Blue Jays-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Houston Astros’ Christian Walker crushed a two-run homer that tied the game against the San Diego Padres.

Blue Jays vs. Astros Game Information & Odds

When: Tuesday, April 22, 2025 at 8:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: SCHN and SN1

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Blue Jays -111 -108 8 -116 -105 -1.5 +146 -176

Blue Jays vs. Astros Prediction

Score Prediction: Astros 5, Blue Jays 4
Total Prediction: Over 8 runs
Win Probabilities: Blue Jays 57%, Astros 43%

Blue Jays vs. Astros Betting Insights

The Blue Jays have entered the game as favorites seven times this season and won five of those games.
Toronto is 5-2 this season when entering a game favored by -111 or more on the moneyline.
The implied probability of a win from the Blue Jays, based on the moneyline, is 52.6%.
The Astros have been chosen as underdogs in eight games this year and have walked away with the win four times (50%) in those games.
Houston has a win-loss record of 4-3 when favored by -108 or worse by oddsmakers this year.
Bookmakers have implied with the moneyline set for this matchup that the Astros have a 51.9% chance of pulling out a win.

Blue Jays Recent Betting Performance

The Blue Jays have been listed as the moneyline favorite by oddsmakers only once in the last 10 games, and won that matchup.
Over their last 10 matchups (all had set totals), the Blue Jays combined with their opponents to go over the total six times.
The Blue Jays have a 6-4-0 record against the spread over their past 10 games.

Blue Jays Recent Stats

Stat Avg/Total Record 4-6 Runs Per Game 3.7 HR 6 ERA 4.30 K/9 10.3

Blue Jays Player Insights

Bo Joseph Bichette has accumulated a team-high 13 runs batted in.
Bichette ranks 272nd in homers and 42nd in RBI among all batters in baseball.
Bichette has collected a hit in six games in a row. During his last 10 outings he is batting .333 with four doubles, two walks and five RBI.
Vladimir Guerrero Jr. has six doubles, a home run and 14 walks while hitting .291.
Of all major league batters, Guerrero ranks 173rd in homers and 90th in RBI.
Andres Gimenez has a team-best three homers.
Springer is batting .349 to lead his team.
Springer has recorded at least one hit in two games in a row. During his last five outings he is hitting .222 with two doubles, three walks and an RBI.

Blue Jays Team Props

Hits O/U Total Bases O/U HR O/U RBI O/U Vladimir Guerrero Jr. 1.5 (+200) 1.5 (+105) – 0.5 (+165) Bo Joseph Bichette 1.5 (+175) 1.5 (+105) – 0.5 (+185) Will Wagner 0.5 (-145) 0.5 (-145) – 0.5 (+270) George Springer 0.5 (-170) 0.5 (-175) – 0.5 (+190) Anthony Santander 0.5 (-175) 0.5 (-180) – 0.5 (+145)

Astros Recent Betting Performance

Over the past 10 games, the Astros have been underdogs twice and split those games 1-1.
In their last 10 games with a total, the Astros and their opponents have combined to hit the over four times.
Over their last 10 games, the Astros are 7-3-0 against the spread.

Astros Recent Stats

Stat Avg/Total Record 6-4 Runs Per Game 4.6 HR 10 ERA 3.07 K/9 8.1

Astros Player Insights

Jeremy Pena has collected a team-best three home runs.
Among all hitters in the big leagues, Pena’s home run total ranks 74th and his RBI tally is 161st.
Pena carries a 12-game hitting streak into this matchup. During his last 10 outings he is hitting .278 with two doubles, a home run, four walks and five RBI.
Jose Carlos Altuve’s three home runs and .303 batting average are both lineup-highs.
Among all major league hitters, Altuve is 74th in home runs and 116th in RBI.
Isaac Paredes leads the Astros in home runs (three) and runs batted in (12).
Yordan Ruben Alvarez has driven in the most runs for the Astros with 12 runs batted in.

Astros Team Props

Hits O/U Total Bases O/U HR O/U RBI O/U Yordan Ruben Alvarez 0.5 (-225) 1.5 (+100) – 0.5 (+135) Yainer Diaz 0.5 (-220) 1.5 (+145) – 0.5 (+185) Jose Carlos Altuve 0.5 (-230) 1.5 (+150) – 0.5 (+235) Mauricio Dubon 0.5 (-160) 0.5 (-165) – 0.5 (+265) Jeremy Pena 0.5 (-195) 0.5 (-200) – 0.5 (+220)

Houston Astros’ Christian Walker crushed a two-run homer that tied the game against the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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