Columbia University’s interim president resigned Friday, becoming the Ivy League school’s second embattled leader to vacate the position as the school remains the target of President Donald Trump and other Republicans over its handling of pro-Palestinian student activism.

The president, Katrina Armstrong, resigned effective immediately, and the school’s board chair, journalist Claire Shipman, has been appointed interim president. Armstrong had replaced Columbia’s former president, Minouche Shafik, who resigned in August.

“Dr. Armstrong accepted the role of interim president at a time of great uncertainty for the University and worked tirelessly to promote the interests of our community,” David Greenwald, chair of Columbia’s board of trustees, said in a statement. “Katrina has always given her heart and soul to Columbia. We appreciate her service and look forward to her continued contributions to the University,” he added.

Armstrong’s resignation was first reported by the Wall Street Journal.

The extraordinary move comes a week after Columbia agreed to a set of nine demands by the Trump administration in order to open talks to un-freeze $400 million in research funding, which the administration had imposed over allegations of antisemitism on campus.

Trump’s joint task force to combat antisemitism welcomed Armstrong’s resignation, calling it “an important step toward advancing negotiations as set forth in the pre-conditional understanding reached last Friday” in a statement.

The school is under multiple federal investigations. And it is also a top target of Trump’s immigration crackdown targeting students involved in pro-Palestinian activism, including Mahmoud Khalil, a former Columbia graduate student and green card holder currently being held in an Immigration and Customs Enforcement facility.

In recent weeks, the State Department has targeted multiple other Columbia students with visas for deportation over alleged “pro-Hamas” sentiment, and the university has confirmed the presence of Department of Homeland Security agents on campus.

Armstrong is the fourth Ivy League president to resign amid Republican pressures over the schools’ responses to pro-Palestinian student activism. Last school year, the presidents of Harvard and the University of Pennsylvania stepped down after being grilled by the House education panel.

Shafik, who also faced the panel’s questioning, managed to hang onto her job through the end of the 2023-2024 academic year, but she received sharp criticism for her management of a student encampment that cast the campus into the center of a national political firestorm. It ended with a stunning display as New York Police Department officers dragged students out of an academic building they had occupied.

Armstrong later apologized to people “hurt” by the NYPD sweeps.